Vol. 9, 2024

Medical Physics

THE APPLICATION OF AI-BASED TECHNIQUES FOR EARLY DETECTION OF BREAST CANCER

Dafina Xhako, Elda Spahiu, Suela Hoxhaj, Niko Hyka

Pages: 29-35

DOI: 10.37392/RapProc.2024.07

Breast cancer is a type of tumor that occurs in breast tissue. It continues to remain one of the most prevalent and life-threatening diseases globally, becoming the second leading cause of cancer-related deaths among women. Breast cancer begins when malignant and cancerous cells begin to grow from the breast cells. Self-tests and periodic clinical examinations help in early diagnosis and significantly improve survival chances. Early diagnosis of breast cancer, when it is small and has not spread, can make the disease easier to treat, thus increasing the patient’s chances of survival. Due to the medical importance of breast cancer examinations, Computer-Aided Detection methods have been developed to detect anomalies such as calcifications, masses, architectural distortions, and bilateral asymmetry. Micro calcifications are nothing but tiny mineral deposits within the breast tissue. They look like small white colored spots. They may or may not be caused by cancer. This is one reason why breast cancer detection is difficult with mammogram because the mammogram results vary greatly depending on the patient’s age, breast density, and the type of lesion present. Breast density can lead to differences in the contrast of malignant regions and can lead to incorrect conclusions. Our study describes an AI approach of adaptive median filter which performs spatial processing to determine which pixels in an image have been affected by noise. To detect a tumor at different stages we use neural network with different learning techniques to get Gaussian Mixed Model (GMM) segmentation. The Artificial Neural Network (ANN) model is based on convolutional neural networks (CNN) and as input data we have selected 260 mammogram images classifying them into three categories: normal mammogram, mammogram with benign and mammogram with cancer. After the training process, we used a CNN model named ResNet50 to compare the results. Due to the low processing capacity, we have chosen a small dataset. Our results show that a CNN model with 3*3 convolutional layer performed better compared with Gaussian Mixed Model segmentation.
  1. H. Sung et al., “Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries,” CA Cancer J. Clin., vol. 71, no. 3, pp. 209 – 249, May 2021.
    DOI: 10.3322/caac.21660
    PMid: 33538338
  2. A. Y. Ng et al., “Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer,” Nat. Med., vol. 29, no. 12, pp. 3044 – 3049, Dec. 2023.
    DOI: 10.1038/s41591-023-02625-9
    PMid: 37973948
    PMCid: PMC10719086
  3. J. S. Ahn et al., “Artificial Intelligence in Breast Cancer Diagnosis and Personalized Medicine,” J. Breast Cancer, vol. 26, no. 5, pp. 405 – 435, Oct. 2023.
    DOI: 10.4048/jbc.2023.26.e45
    PMid: 37926067
    PMCid: PMC10625863
  4. J. Tang, R. M. Rangayyan, J. Xu, I. El Naqa, Y. Yang, “Computer-aided detection and diagnosis of breast cancer with mammography: recent advances,” IEEE Trans. Inf. Technol. Biomed., vol. 13, no. 2, pp. 236 – 251, Mar. 2009.
    DOI: 10.1109/TITB.2008.2009441
    PMid: 19171527
  5. I. Kim, K. Kang, Y. Song, T.-J. Kim, “Application of artificial intelligence in pathology: trends and challenges,” Diagnostics, vol. 12, no. 11, 2794, Nov. 2022.
    DOI: 10.3390/diagnostics12112794
    PMid: 36428854
    PMCid: PMC9688959
  6. N. Houssami, G. Kirkpatrick-Jones, N. Noguchi, C. I. Lee, “Artificial Intelligence (AI) for the early detection of breast cancer: a scoping review to assess AI’s potential in breast screening practice,” Expert Rev. Med. Devices, vol. 16, no. 5, pp. 351 – 362, May 2019.
    DOI: 10.1080/17434440.2019.1610387
    PMid: 30999781
  7. L. Shen et al., “Deep Learning to improve breast cancer early detection on screening mammography,” Sci. Rep., vol. 9, no. 1, 12495, Aug. 2019.
    DOI: 10.1038/s41598-019-48995-4
    PMid: 31467326
    PMCid: PMC6715802
  8. C. Leibig et al., “Combining the strengths of radiologists and AI for breast cancer screening: A retrospective analysis,” Lancet Digit. Health, vol. 4, no. 7, pp. e507 – e519, Jul. 2022.
    DOI: 10.1016/S2589-7500(22)00070-X
    PMid: 35750400
    PMCid: PMC9839981
  9. Y. Qiu et al., “A new approach to develop computer-aided diagnosis scheme of breast mass classification using deep learning technology,” J. Xray Sci. Technol., vol. 25, no. 5, pp. 751 – 763, Jan. 2017.
    DOI: 10.3233/XST-16226
    PMid: 28436410
    PMCid: PMC5647205
  10. D. Ribli, A. Horváth, Z. Unger, P. Pollner, I. Csabai, “Detecting and classifying lesions in mammograms with deep learning,” Sci. Rep., vol. 8, no. 1, 4165, Mar. 2018.
    DOI: 10.1038/s41598-018-22437-z
    PMid: 29545529
    PMCid: PMC5854668
  11. N. Houssami, C. I. Lee, D. S. M. Buist, D. Tao, “Artificial intelligence for breast cancer screening: opportunity or hype?” Breast, vol. 36, pp. 31 – 33, Dec. 2017.
    DOI: 10.1016/j.breast.2017.09.003
    PMid: 28938172
  12. D. Zheng, X. He, J. Jing, “Overview of artificial intelligence in breast cancer medical imaging,” J. Clin. Med., vol. 12, no. 2, 419, Jan. 2023.
    DOI: 10.3390/jcm12020419
    PMid: 36675348
    PMCid: PMC9864608
  13. M. Ghassemi et al., “A review of challenges and opportunities in machine learning for health,” deposited at arXiv, Dec. 5, 2019. arXiv:1806.00388
  14. R. Agarwal, O. Diaz, X. Lladó, M. H. Yap, R. Martí, “Automatic mass detection in mammograms using deep convolutional neural networks,” J. Med. Imaging, vol. 6, no. 3, 031409, Jul. 2019.
    DOI: 10.1117/1.JMI.6.3.031409
    PMid: 35834317
    PMCid: PMC6381602
  15. C. R. Taylor, N. Monga, C. Johnson, J. R. Hawley, M. Patel, “Artificial Intelligence Applications in Breast Imaging: Current Status and Future Directions,”Diagnostics, vol. 13, no. 12, 2041, Jun. 2023.
    DOI: 10.3390/diagnostics13122041
    PMid: 37370936
    PMCid: PMC10296832
  16. J. W. Li et al., “Artificial intelligence in breast imaging: Potentials and challenges,” Phys. Med. Biol., vol. 68, no. 23, 23TR01, Nov. 2023.
    DOI: 10.1088/1361-6560/acfade
    PMid: 37722385
  17. A. Yala, C. Lehman, T. Schuster, T. Portnoi, R. Barzilay, “A deep learning mammography-based model for improved breast cancer risk prediction,” Radiology, vol. 292, no. 1, pp. 60 – 66, Jul. 2019.
    DOI: 10.1148/radiol.2019182716
    PMid: 31063083
  18. D. Xhako, S. Hoxhaj, N. Hyka, E. Spahiu, P. Malkaj, “Artificial Intelligence in Medical Image Processing,” Int. J. Intell. Syst. Appl. Eng., vol. 12, no. 8s, pp. 549 – 552, Dec. 2023.
    Retrieved from: https://ijisae.org/index.php/IJISAE/article/view/4186
    Retrieved on: Feb. 10, 2024
  19. D. Xhako, N. Hyka, “Artificial neural networks application in medical images,” Int. J. Health Sci., vol. 6, no. S2, pp. 10632 – 10639, May 2022.
    DOI: 10.53730/ijhs.v6nS2.7829
  20. N. Dhungel, G. Carneiro, A. P. Bradley, “A deep learning approach for the analysis of masses in mammograms with minimal user intervention,” Med. Image Anal., vol. 37, pp. 114 – 128, Apr. 2017.
    DOI: 10.1016/j.media.2017.01.009
    PMid: 28171807
  21. D. Xhako, E. Spahiu, N. Hyka, S. Hoxhaj, P. Malkaj, “Integration of DCNN Model for Brain Tumor Detection with PPIR Simulator,” Int. J. Intell. Syst. Appl. Eng., vol. 12, no. 8s, pp. 534 – 538, Dec. 2023.
    Retrieved from: https://ijisae.org/index.php/IJISAE/article/view/4184
    Retrieved on: Feb. 10, 2024
  22. F. Valdora, N. Houssami, F. Rossi, M. Calabrese, A. S. Tagliafico, “Rapid review: Radiomics and breast cancer,” Breast Cancer Res. Treat., vol. 169, no. 2, pp. 217 – 229, Jun. 2018.
    DOI: 10.1007/s10549-018-4675-4
    PMid: 29396665
  23. W. L. Bi. et al., “Artificial intelligence in cancer imaging: Clinical challenges and applications,” CA Cancer J. Clin., vol. 69, no. 2, pp. 127 – 157, Mar. 2019.
    DOI: 10.3322/caac.21552
    PMid: 30720861
    PMCid: PMC6403009
  24. S. B Shamir, A. L. Sasson, L. R. Margolies, D. S. Mendelson, “New Frontiers in Breast Cancer Imaging: The Rise of AI,” Bioengineering, vol. 11, no. 5, 451, May 2024.
    DOI: 10.3390/bioengineering11050451
    PMid: 38790318
    PMCid: PMC11117903