Introduction. Whooping cough (pertussis) is a contagious respiratory disease caused by Bordatella pertussis, a gram-negative bacterium. It can occur at any age. The clinical picture is diverse, with a wide range of symptoms and severity, especially in newborns, infants, and the elderly. Due to the potential complications, a high morbidity and mortality rate of this disease has been recorded in developed and developing countries. The diagnosis is made based on the clinical picture and confirmed by a nasal swab or a nasopharyngeal aspirate, PCR detection, or serological tests. Epidemics occur worldwide every 3 to 5 years. Early detection of the disease itself and appropriate and rapid treatment with suitable antibiotics are key to success in controlling the epidemic. Objective. To determine whether, with the emergence of COVID-19, the rate of vaccinations and booster vaccinations against whooping cough according to the prescribed vaccination calendar on Šumadija District. County has decreased compared to previous years before the outbreak of the coronavirus pandemic. Results and Discussion. Prevention of this disease is childhood vaccination according to the vaccination calendar prescribed in our country. Whooping cough is a notifiable disease in the Republic of Serbia and is recorded in the Report on Infectious Diseases of the Institute of Public Health of Serbia “Dr. Milan Jovanović-Batut”. The incidence of diseases in Serbia has steadily decreased since the introduction of compulsory vaccination in the middle of the 20th century. The pertussis vaccine has proven to be an effective and powerful weapon in the fight against whooping cough in all age groups. The statistical data obtained shows that the vaccination coverage rate in the first year of life was 89% in 2021, compared to 2018 when it was 98% in the first year of life. Booster vaccination in the second year of life was 90% in 2021 compared to 98% in 2018 in the Šumadija District. According to the latest vaccination guidelines and considering the recurrence and spread rate of this disease, as well as possible complications in certain systems, we should talk about the possibility of supplementary vaccination at some point in life. Conclusion. Based on the processed data, it can be stated that children’s response to vaccination and booster vaccination has decreased during the COVID-19 pandemic in the Šumadija District. It is necessary to check the vaccination status and thus improve immunity against this disease to reduce the possibility of the occurrence and spread of the said disease on an epidemic scale, which is extremely serious in newborns, young children, and the elderly.

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