Vol. 5, 2020

Biochemistry

ANTIMICROBIAL ACTIVITY AND REDOX PROPERTY OF Ni(II) COMPLEXES WITH ORTHO- AND META-DIPHENOL DERIVATIVES

K.A. Nabebina, N.V. Loginova, T.V. Kovalchuk-Rabchinskaya, G.A. Ksendzova, N.P. Osipovich

Pages: 64-67

DOI: 10.37392/RapProc.2020.15

The redox-activity of novel bioactive Ni(II) complexes with ortho- and meta-diphenols was investigated. Amorphous water insoluble complexes with general formula NiL2 were synthesized according to the authorial method. It was found that the complexes are highly lipophilic (lgPow= 2.5÷3.5), stable in water-organic media (stability constants logarithm lgβ=15-18) and have a non-electrolyte nature. Voltammetry analysis was used to determine the first oxidation peak (Epa1, V) as a thermodynamic criterion of compounds’ reducing ability. It was found that complexes with ortho-diphenol derivatives possess stronger reducing ability then the complexes with meta-diphenol. Antimicrobial activity of Ni(II) complexes against Mycobacterium smegmatis and Candida albicans were evaluated. Intricate dependence between reducing ability and bactericidal activity was found.
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