Vol. 4, 2019

Original research papers

Radiation in Medicine

PRE-CLINICAL BNCT GLIOBLASTOMA RESEARCH. ICP-AES BORON DETERMINATION METHOD. STUDIES ON 10B BORON BIODISTRIBUTION IN MICE’S ORGANS

А. Tsygankova, V. Каnygin, А. Каsatova, Е. Zavjalov, Т. Guselnikova, А. Kichigin, R. Mukhamadiyarov

Pages: 23–29

DOI: 10.37392/RapProc.2019.06

To accompany boron neutron capture therapy for cancerous tumours, there has been an optimised ICP-AES method for boron determination in animals’ organs tissues. This technique is characterised by its universalism. The approach comprises preliminary acid decomposition at high temperatures and pressure (if necessary), ICP-AES boron determination in the gained solutions analysing comparative samples basing on a single element solution. Its validity is proved by the spike experiment and mass sample variation test. The ICP-AES method is used during the evaluation of BPA and BSH accumulation in organs and tissues when intravenously injecting U87 glioblastoma medication to SCID mice of SPF-status.
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